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Frizzled class receptor 1
Symbols FZD1 ; DKFZp564G072; FLJ95923
External IDs OMIM603408 MGI1196625 HomoloGene20750 IUPHAR: 229 GeneCards: FZD1 Gene
RNA expression pattern
PBB GE FZD1 204451 at tn.png
PBB GE FZD1 204452 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8321 14362
Ensembl ENSG00000157240 ENSMUSG00000044674
UniProt Q9UP38 O70421
RefSeq (mRNA) NM_003505 NM_021457
RefSeq (protein) NP_003496 NP_067432
Location (UCSC) Chr 7:
90.89 – 90.9 Mb
Chr 5:
4.75 – 4.76 Mb
PubMed search [1] [2]

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.[1][2]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[2]

See also[edit]


  1. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155. 
  2. ^ a b "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)". 

External links[edit]

  • "Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.