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Frizzled class receptor 8
Protein FZD8 PDB 1ijy.png
PDB rendering based on 1ijy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FZD8 ; FZ-8; hFZ8
External IDs OMIM606146 MGI108460 HomoloGene40606 IUPHAR: FZD8 GeneCards: FZD8 Gene
RNA expression pattern
PBB GE FZD8 216587 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8325 14370
Ensembl ENSG00000177283 ENSMUSG00000036904
UniProt Q9H461 Q61091
RefSeq (mRNA) NM_031866 NM_008058
RefSeq (protein) NP_114072 NP_032084
Location (UCSC) Chr 10:
35.93 – 35.93 Mb
Chr 18:
9.21 – 9.22 Mb
PubMed search [1] [2]

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

See also[edit]


  1. ^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol 18 (5): 991–6. doi:10.3892/ijo.19.1.105. PMID 11295046. 
  2. ^ a b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)". 

External links[edit]

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.