FZD9

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Frizzled family receptor 9
Identifiers
Symbols FZD9 ; CD349; FZD3
External IDs OMIM601766 MGI1313278 HomoloGene2619 IUPHAR: FZD9 GeneCards: FZD9 Gene
RNA expression pattern
PBB GE FZD9 207639 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8326 14371
Ensembl ENSG00000188763 ENSMUSG00000049551
UniProt O00144 Q9R216
RefSeq (mRNA) NM_003508 NM_010246
RefSeq (protein) NP_003499 NP_034376
Location (UCSC) Chr 7:
72.85 – 72.85 Mb
Chr 5:
135.25 – 135.25 Mb
PubMed search [1] [2]

Frizzled-9 is a protein that in humans is encoded by the FZD9 gene.[1][2][3] FZD9 has also been designated as CD349 (cluster of differentiation 349).

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.[3]

See also[edit]

References[edit]

  1. ^ Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U (May 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Hum Mol Genet 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651. 
  2. ^ Wang YK, Sporle R, Paperna T, Schughart K, Francke U (May 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163. 
  3. ^ a b "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.