Fadrozole

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Fadrozole
Fadrozole structure.svg
Systematic (IUPAC) name
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Clinical data
  • (Prescription only)
Oral
Identifiers
102676-31-3 YesY
None
PubChem CID 59693
ChemSpider 53850 N
UNII H3988M64PU N
KEGG D02451 YesY
ChEMBL CHEMBL9298 N
Chemical data
Formula C14H13N3
223.27 g/mol
 N (what is this?)  (verify)

Fadrozole (INN, marketed as Afema by Novartis) is an aromatase inhibitor[1] that has been introduced in Japan for the treatment of breast cancer.

It is selective.[2]

References[edit]

  1. ^ Raats JI, Falkson G, Falkson HC (January 1992). "A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer". J. Clin. Oncol. 10 (1): 111–6. PMID 1530798. 
  2. ^ Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A (February 1991). "Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease". J. Med. Chem. 34 (2): 725–36. doi:10.1021/jm00106a038. PMID 1825337. 

See also[edit]