Faget sign

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In medicine, the Faget sign — sometimes called sphygmothermic dissociation — is the unusual pairing of fever and bradycardia (slow pulse). It is often seen in yellow fever.

Fever is usually accompanied by tachycardia (a fast pulse), an association known by the eponym Liebermeister's rule.

Faget sign is also seen in:

It is named after Jean Charles Faget, who characterized it in 1859.[2][3]


  1. ^ Neuroimmunomodulation. 1999 Jul-Aug;6(4):305-17. Beta-adrenergic receptor subtype effects on stress fever and thermoregulation. Mayfield KP, Soszynski D, Kozak W, Kozak A, Rudolph K, Kluger MJ.
  2. ^ synd/3753 at Who Named It?
  3. ^ Jean-Charles Faget. Études médicale de quelques questions importantes pour la Louisiane, et exposé succinct d’une endémie paludéenne de forme catarrhale qui a sévi à la Nouvelle-Orléans, particulièrement sur les enfants, pendant l’epidémie de fièvre jaune de 1858. New Orleans, 1859.