Farafangana is a city (commune urbaine) on the south-east coast of Madagascar approximately 400 kilometres south of the capital Antananarivo. It is the capital of the Atsimo-Atsinanana region.
Settlements located to the north include Lokandambo, Manambotra, Ambahikarabo and Amboahangimamy, with Ambalolo to the west. To the south are Antananabo, Manambotra Atsimo and Marosondry.
The Roman Catholic Diocese of Farafangana is based in the town, led by Bishop Benjamin Marc Ramaroson.
The population essentially consists of three ethnic groups: the Antefasy, Rabakara and Zafisoro.
There is an airport in Farafangana. One of the main crops of the region of Farafangana is pepper.
The Manombo Reserve is located at 25 km to Farafangana.
Coordinates: 22°49′S 47°49′E / 22.817°S 47.817°E