FM 757 begins at an intersection with SH 31 in Smith County, where the road continues south as CR 21 (Red Bird Road). From this intersection, the route heads north on a two-lane undivided road, heading through wooded areas with some small fields and homes. The highway crosses FM 2767 and continues through more rural areas. FM 757 heads into a mix of farmland and woodland as it comes to an interchange with I-20. Past this interchange, the road runs between farms to the west and woods to the east, intersecting the western terminus of FM 1252 before crossing US 271. FM 757 runs through more agricultural and wooded areas, ending at an intersection with FM 16 in Starrville.
The route (former War Highway 17) was designated in 1947 from US 271 to SH 31. In 1948, FM 757 was extended 1.8 miles from Starrville to US 271. The final change came in 1963, when FM 757 was extended to a rerouted SH 31, bringing FM 757 to its current configuration.