fatty-acid-binding proteins ( FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. [1 ] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular [2 ] membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain [3 ] intracellular receptors such as PPAR. Levels of fatty-acid-binding protein have been shown to decline with [4 ] ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity. [5 ]
Family members [ edit ]
Members of this family include:
References [ edit ]
^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. doi: 10.1007/BF03194597. PMID 16424607.
^ Smathers RL, Petersen DR (2011). "The human fatty acid-binding protein family: evolutionary divergences and functions". Hum Genomics 5 (1): 170–191. doi: 10.1186/1479-7364-5-3-170. PMID 21504868.
^ Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi: 10.1023/A:1020550405578. PMID 12479566.
^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi: 10.1128/MCB.22.14.5114-5127.2002. PMC 139777. PMID 12077340.
^ Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (August 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Mol. Cell. Biochem. 198 (1-2): 69–78. doi: 10.1023/A:1006946027619. PMID 10497880.
External links [ edit ]