Fcα/μR

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Fc receptor, IgA, IgM, high affinity
Identifiers
Symbol FCAMR, CD351
Entrez 83953
HUGO 24692
OMIM 605484
RefSeq NM_032029
UniProt Q96SA2
Other data
Locus Chr. 1 q32.1

Fcα/μR, also known as is CD351 (Cluster of Differentiation 351), is an Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity.[1] In mice the receptor is expressed on macrophages, follicular dendritic cells, marginal zone and follicular B cells and kidney tubular epithelial cells. In humans expressed has been described on intestinal lamina propria cells, Paneth cells, follicular dendritic cells in tonsils, activated macrophages and some types of pre-germinal centre IgD+/CD38+ B cells.

References[edit]

  1. ^ Yang, Xi; Zhao, Qing; Zhu, Liping; Zhang, Wei (May 2013). "The three complementarity-determining region-like loops in the second extracellular domain of human Fc alpha/mu receptor contribute to its binding of IgA and IgM". Immunobiology 218 (5): 798–809. doi:10.1016/j.imbio.2012.09.004. PMID 23182711. 

External links[edit]