Fedotozine

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Fedotozine
Fedotozine structure.svg
Systematic (IUPAC) name
(2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine
Clinical data
Legal status Non-regulated
Routes Oral
Identifiers
CAS number 123618-00-8
133267-27-3 (tartrate)
ATC code None
PubChem CID 6918160
ChemSpider 5293373
ChEMBL CHEMBL2106275
Chemical data
Formula C22H31NO4 
Mol. mass 373.486 g/mol

Fedotozine (INN; Jo-1196) is an opioid drug of the arylacetamide series which acts as a peripherally-specific, selective κ1-opioid receptor agonist with preference for the κ1A subtype.[1] It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials,[1][2][3] but ultimately development was discontinued and it was never marketed.

See also[edit]

References[edit]

  1. ^ a b Delvaux M (January 2001). "Pharmacology and clinical experience with fedotozine". Expert Opinion on Investigational Drugs 10 (1): 97–110. doi:10.1517/13543784.10.1.97. PMID 11116283. 
  2. ^ Barber A, Gottschlich R (October 1997). "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opinion on Investigational Drugs 6 (10): 1351–68. doi:10.1517/13543784.6.10.1351. PMID 15989506. 
  3. ^ Lembo A (2006). "Peripheral opioids for functional GI disease: a reappraisal". Digestive Diseases (Basel, Switzerland) 24 (1-2): 91–8. doi:10.1159/000090312. PMID 16699267.