||This article needs additional citations for verification. (May 2011)|
|Feline panleukopenia virus|
|Group:||Group II (ssDNA)|
|Species:||Feline panleukopenia virus|
Feline panleukopenia virus (FPV), also known as Feline infectious enteritis, Feline distemper, feline ataxia, or cat plague, is a viral infection affecting cats, both domesticated and wild feline species. It is caused by feline parvovirus, a close relative of both type 2 canine parvovirus and mink enteritis. Once contracted, it is highly contagious and can be fatal to the affected cat. The name, panleucopenia, comes from the low white blood cell count (leucocytes) exhibited by affected animals.
Transmission and Clinical Signs 
Panleukopenia is primarily spread through contact with an infected animal's bodily fluids, feces, or other fomites, as well as by fleas. It may be spread to and by cats, minks and ferrets and can be spread long distances through contact with bedding, food dishes, or even by clothing and shoes of handlers of infected animals. It is not, however, contagious or contractable by humans. Like all parvoviruses, FPV is extremely resistant to inactivation and can survive for longer than one year in a suitable environment.
The virus primarily attacks the lining of the gastrointestinal tract, causing internal ulceration and, ultimately, total sloughing of the intestinal epithelium. This results in profuse and usually bloody diarrhea, severe dehydration, malnutrition, anemia, and often death. It causes a decrease in the cat's white blood cells, thus compromising its immune system. Typically, it also causes a decrease in hematocrit and platelet counts on a complete blood count. This is often key in diagnosing panleukopenia. Other symptoms include depression, lethargy, loss of appetite, fever, vomiting, loss of skin elasticity due to dehydration, and self-biting in the tail, lower back and back legs. Affected cats may sit for hours at their water bowl, although they may not drink much. Terminal cases are hypothermic and may develop septic shock and disseminated intravascular coagulation. Most panleukopenia deaths are due to secondary infections or dehydration resulting from diarrhea. This is because the virus affects the infected cat's immune system, leaving it vulnerable to secondary infection.
If a cat is exposed during pregnancy, the virus can cause cerebellar hypoplasia in her offspring. This is why administering modified live feline panleukopenia vaccine during pregnancy is discouraged. Feline panleukopaenia and canine parvovirus are extremely closely related, but viruses cannot be transmitted between dogs and cats.
|This section requires expansion. (January 2011)|
Generally, a clinical diagnosis of feline panleukopenia [FPL] can be made based on characteristic gastroenteric illness and severe pancytopenia in a susceptible cat, but fecal analysis and blood culture is typically performed as well to rule out other illnesses. Differential diagnoses for FPL include salmonellosis, enteric toxosis, FIV, feline leukemia, cryptosporidiosis, pancreatitis, septicaemia with acute endotoxemia, toxoplasmosis, peritonitis, and lymphoma. In an unvaccinated cat, the presence of antibodies against FPLV indicate that the cat either has the disease or has had the disease in the past, but in many cases subclinical disease occurs so this test is unreliable.
Protection is offered by commercial feline distemper vaccines (ATCvet codes: QI06 for the inactivated viral vaccine and QI06 for the live vaccine). A number of combination vaccines for several different diseases, including panleukopenia, are also available.
|This section requires expansion. (January 2011)|
Feline panleukopenia requires aggressive treatment if the cat is to survive, as this disease can kill cats in less than 24 hours. Treatment involves whole blood transfusion to improve pancytopenia, intravenous fluids as most cats are dehydrated, injections of vitamins A, B, and C, IV antibiotics to prevent septicemia, which develops in most cats with feline panleukopenia if antibiotics are not used, and hospitalization.
Of affected kittens that are two months or less of age, 95% die regardless of treatment. Kittens that are more than two months old have a 60-70% mortality rate with treatment and a nearly 100% mortality rate if not treated. Adult cats have a 10-20% mortality rate if treated, and an 85% mortality rate if not treated. Elderly cats have a 20-30% mortality rate if treated and a 90% mortality rate if not treated.
Complications are quite common in feline panleukopenia [FPL]. The most prevalent one is dehydration, which develops in almost all FPL-infected cats that are clinically ill. Hyponatremia and other electrolyte disturbances are also quite common, as is hypotension, hyperpyrexia or, late in the disease, hypothermia. The patients' severe leukocytopenia predispose them to secondary infections, especially bacterial and fungal, though secondary viral infections also occur with some frequency. Disseminated intravascular coagulation may also occur, and is often fatal. Extreme thrombocytopenia may also occur, and can lead to severe hemorrhagic complications. Even if a cat survives acute FPL, late complications such as cardiomyopathy and myocarditis can occur, though there have never been any reported cases of hematologic or gastrointestinal sequalae, and it seems that late myocarditis or cardiomyopathy is extremely rare in feline panleukopenia-affected cats. Overall, any long-term sequalae in survivors of feline panleukopenia is extremely rare, with almost all cats who survive making a full recovery.
Prince Edward Islands 
At the beginning of the 1980s, cats brought to Marion Island, one of the Prince Edward Islands, to deal with a mouse problem in the local meteorological station, went out of growth control. Starting from the first five domestic cats introduced on the island on 1949, there were about 3,400 cats in 1977, feeding on the burrowing petrels instead of the mice, threatening to drive the birds to extinction. A cat eradication program was set up and few cats were intentionally infected with the panleukopenia virus, which reduced the number of cats to about 600 by 1982.(inactive link)
- "Feline Panleukopenia: Introduction". Whitehouse Station, NJ USA: Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. Retrieved 26 May 2011.
- "Feline Panleukopenia (feline enteritis, feline distemper) in Cats- Causes, Symptoms & Treatment". Retrieved 26 May 2011.
- "Treatment Options for Feline Panleukopenia (Distemper)". VetInfo. Retrieved 30 May 2011.
- K Berthier, M Langlais, P Auger, D Pontier (2000-10-22). "Dynamics of a feline virus with two transmission modes within exponentially growing host populations". BioInfoBank Library.
- American Veterinary Medical Association brochure on Feline Panluekopenia
- Feline Distemper (Panleukopenia) from The Pet Health Library
- Pawprints and Purrs, Inc. Cat Health Care FAQ
- AVMA article on the benefits and risks of feline vaccines
- Feline panleukopenia (Felipedia.org)