Feline sarcoma oncogene

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FES proto-oncogene, tyrosine kinase
Protein FES PDB 1wqu.png
PDB rendering based on 1wqu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FES ; FPS
External IDs OMIM190030 MGI95514 HomoloGene37563 ChEMBL: 5455 GeneCards: FES Gene
EC number
RNA expression pattern
PBB GE FES 205418 at tn.png
More reference expression data
Species Human Mouse
Entrez 2242 14159
Ensembl ENSG00000182511 ENSMUSG00000053158
UniProt P07332 P16879
RefSeq (mRNA) NM_001143783 NM_010194
RefSeq (protein) NP_001137255 NP_034324
Location (UCSC) Chr 15:
91.43 – 91.44 Mb
Chr 7:
80.38 – 80.39 Mb
PubMed search [1] [2]

Proto-oncogene tyrosine-protein kinase Fes/Fps is an enzyme that in humans is encoded by the FES gene.[1][2]

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[2]


Feline sarcoma oncogene has been shown to interact with BCAR1[3] and BCR gene.[4][5]


  1. ^ Bowden DW, Akots G, Rothschild CB (September 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Res 19 (15): 4311. doi:10.1093/nar/19.15.4311. PMC 328602. PMID 1870997. 
  2. ^ a b "Entrez Gene: FES feline sarcoma oncogene". 
  3. ^ Jücker, M; McKenna K; da Silva A J; Rudd C E; Feldman R A (January 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". J. Biol. Chem. (UNITED STATES) 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. ISSN 0021-9258. PMID 8999909. 
  4. ^ Lionberger, J M; Smithgall T E (February 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Res. (UNITED STATES) 60 (4): 1097–103. ISSN 0008-5472. PMID 10706130. 
  5. ^ Maru, Y; Peters K L; Afar D E; Shibuya M; Witte O N; Smithgall T E (February 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Mol. Cell. Biol. (UNITED STATES) 15 (2): 835–42. ISSN 0270-7306. PMC 231961. PMID 7529874. 

Further reading[edit]

  • Smithgall TE, Rogers JA, Peters KL et al. (1998). "The c-Fes family of protein-tyrosine kinases". Critical reviews in oncogenesis 9 (1): 43–62. doi:10.1615/critrevoncog.v9.i1.40. PMID 9754447. 
  • Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136. 
  • Greer P (2002). "Closing in on the biological functions of Fps/Fes and Fer". Nat. Rev. Mol. Cell Biol. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.