Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FESgene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.
^Craig AW. "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience17. PMID22201778.
^Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA (Jan 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID8999909.
^Lionberger JM, Smithgall TE (Feb 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research60 (4): 1097–103. PMID10706130.
Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM et al. (1998). "The c-Fes family of protein-tyrosine kinases". Critical Reviews in Oncogenesis9 (1): 43–62. doi:10.1615/critrevoncog.v9.i1.40. PMID9754447.
Jiang H, Harris MB, Rothman P (Jun 2000). "IL-4/IL-13 signaling beyond JAK/STAT". The Journal of Allergy and Clinical Immunology105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID10856136.
Greer P (Apr 2002). "Closing in on the biological functions of Fps/Fes and Fer". Nature Reviews. Molecular Cell Biology3 (4): 278–89. doi:10.1038/nrm783. PMID11994747.