Proto-oncogene tyrosine-protein kinase Fes/Fps is an enzyme that in humans is encoded by the FESgene.
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.
^Jücker, M; McKenna K, da Silva A J, Rudd C E, Feldman R A (January 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". J. Biol. Chem. (UNITED STATES) 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. ISSN0021-9258. PMID8999909.Cite uses deprecated parameters (help)
^Lionberger, J M; Smithgall T E (February 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Res. (UNITED STATES) 60 (4): 1097–103. ISSN0008-5472. PMID10706130.Cite uses deprecated parameters (help)