Fenbendazole

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Fenbendazole
Fenbendazole.svg
Systematic (IUPAC) name
methyl N-(6-phenylsulfanyl-1H-benzoimidazol-
2-yl)carbamate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 43210-67-9 YesY
ATC code P02CA06 QP52AC13
PubChem CID 3334
ChemSpider 3217 YesY
UNII 621BVT9M36 YesY
KEGG D04140 YesY
ChEBI CHEBI:77092 N
ChEMBL CHEMBL37161 YesY
Chemical data
Formula C15H13N3O2S 
Mol. mass 299.349 g/mol
 N (what is this?)  (verify)

Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the taenia species of tapeworms(It is effective against the Taenia species of tapeworm but not against the common tapeworm, Dipylidium caninum.), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.[1]

Toxicity[edit]

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing.[citation needed] Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.[citation needed]

Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally.[1]

References[edit]

  1. ^ a b Plumb's Veterinary Drug Handbook, Fifth Edition, 2005.

External links[edit]