Fenmetozole

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Fenmetozole
Fenmetozole.png
Systematic (IUPAC) name
2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole
Clinical data
Legal status ?
Identifiers
CAS number 41473-09-0
23712-05-2 (HCl)
ATC code None
PubChem CID 32049
ChemSpider 29721
UNII C15WFN6GMO YesY
ChEMBL CHEMBL50472
Chemical data
Formula C10H10Cl2N2O 
Mol. mass 245.11 g/mol

Fenmetozole (DH-524) is a drug which was patented as an antidepressant,[1][2] but was later studied as an antagonist of the effects of ethanol, though results were poor and it even increased its effects in some cases.[3][4][5][6][7] It acts as an α2-adrenergic receptor antagonist similarly to other imidazoles like idazoxan.[8] It was never marketed.[2]

References[edit]

  1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. 
  2. ^ a b David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9. 
  3. ^ McNamee HB, Mendelson JH, Korn J (June 1975). "Fenmetozole in acute alcholol intoxication in man". Clinical Pharmacology and Therapeutics 17 (6): 735–7. PMID 1095283. 
  4. ^ Griffis LC, Bright TP, Cerimele BJ, Forney RB (September 1978). "Combined effects of fenmetozole and ethanol". Clinical Pharmacology and Therapeutics 24 (3): 350–3. PMID 357069. 
  5. ^ Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA (1980). "An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function". Psychopharmacology 69 (2): 149–55. doi:10.1007/BF00427641. PMID 6256788. 
  6. ^ Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR (1981). "Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex". Alcoholism, Clinical and Experimental Research 5 (3): 386–92. doi:10.1111/j.1530-0277.1981.tb04921.x. PMID 6792942. 
  7. ^ Frye GD, Breese GR (1981). "An evaluation of the locomotor stimulating action of ethanol in rats and mice". Psychopharmacology 75 (4): 372–9. doi:10.1007/BF00435856. PMID 6803283. 
  8. ^ Stillings MR, England CD, Welbourn AP, Smith CF (September 1986). "Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". Journal of Medicinal Chemistry 29 (9): 1780–3. doi:10.1021/jm00159a037. PMID 2875186.