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Ferrocyanide is the name of the anion Fe(CN)64−. In aqueous solutions, this coordination complex is relatively unreactive. It is usually available as the salt potassium ferrocyanide, which has the formula K4Fe(CN)6.

Ferrocyanide was not named as a compound of iron and cyanide; rather cyanides as a chemical class were named because they were discovered in ferrocyanide. Ferrocyanide in turn was an iron radical found in the analysis of the intensely blue dye Prussian blue, and named in Latin to mean "blue substance with iron." The dye had been first accidentally made in the early 18th century from substances containing iron, carbon, and nitrogen, and the (then unknown) cyanide formed during the manufacture of the dye. The word "cyanide" used in the name is from kyanos, Greek for "(dark) blue," and is thus named for the Prussian blue dye in which this chemical radical was first discovered.

The ferrocyanide anion itself, when not complexed with iron cations, is colored a moderate yellow.

Redox chemistry[edit]

Ferrocyanide may suffer oxidation, resulting in ferricyanide:

[Fe(CN)6]4− [Fe(CN)6]3− + e

This conversion can be followed spectroscopically at 420 nm, since ferrocyanide has negligible absorption while ferricyanide has an extinction coefficient of 1040 M−1 cm−1.[1]

Coordination chemistry[edit]

[Fe(CN)6]4− is a diamagnetic species, featuring low-spin iron(II) center in an octahedral ligand environment. Although many salts of cyanide are highly toxic, ferro- and ferricyanides are less toxic because they tend not to release free cyanide.[2]

Treatment of ferrocyanide with ferric-containing salts gives the intensely coloured pigment Prussian blue [2] (ferric ferrocyanide or ferrous ferricyanide).

Use in biochemical research[edit]

Ferrocyanide and its oxidized product ferricyanide cannot freely pass through the plasma membrane. For this reason ferrocyanide has been used as a probe of extracellular electron receptor in the study of redox reactions in cells. Ferricyanide is used thus any increase in ferrocyanide can be attributed to secretions of reductants or transplasma membrane electron transport activity.


According to the recommendations of IUPAC, ferrocyanide should be called "hexacyanoferrate(II)."

See also[edit]


  1. ^ Appleby, C. A., and Morton, R. K., Lactic dehydrogenase and cytochrome b2 of baker's yeast: Purification and crystallization. Biochem. J., 71, 492-499 (1959).
  2. ^ a b Holleman, A. F.; Wiberg, E. (2001). Inorganic Chemistry. San Diego: Academic Press. ISBN 0-12-352651-5.