Fibrinogen alpha chain

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Fibrinogen alpha chain
Protein FGA PDB 1fza.png
PDB rendering based on 1fza.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FGA ; Fib2
External IDs OMIM134820 MGI1316726 HomoloGene428 ChEMBL: 1831 GeneCards: FGA Gene
RNA expression pattern
PBB GE FGA 205650 s at tn.png
PBB GE FGA 205649 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2243 14161
Ensembl ENSG00000171560 ENSMUSG00000028001
UniProt P02671 E9PV24
RefSeq (mRNA) NM_000508 NM_001111048
RefSeq (protein) NP_000499 NP_001104518
Location (UCSC) Chr 4:
155.5 – 155.51 Mb
Chr 3:
83.03 – 83.03 Mb
PubMed search [1] [2]

Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.


The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.[1]


Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator.[2][3]

See also[edit]


  1. ^ "Entrez Gene: FGA fibrinogen alpha chain". 
  2. ^ Tsurupa G, Medved L (Jan 2001). "Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains". Biochemistry 40 (3): 801–808. doi:10.1021/bi001789t. PMID 11170397. 
  3. ^ Ichinose A, Takio K, Fujikawa K (Jul 1986). "Localization of the binding site of tissue-type plasminogen activator to fibrin". The Journal of Clinical Investigation 78 (1): 163–169. doi:10.1172/JCI112546. PMC 329545. PMID 3088041. 

Further reading[edit]