FMOD (gene)

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Fibromodulin
Identifiers
Symbols FMOD ; FM; SLRR2E
External IDs OMIM600245 MGI1328364 HomoloGene1530 GeneCards: FMOD Gene
RNA expression pattern
PBB GE FMOD 202709 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2331 14264
Ensembl ENSG00000122176 ENSMUSG00000041559
UniProt Q06828 P50608
RefSeq (mRNA) NM_002023 NM_021355
RefSeq (protein) NP_002014 NP_067330
Location (UCSC) Chr 1:
203.31 – 203.32 Mb
Chr 1:
134.04 – 134.05 Mb
PubMed search [1] [2]

Fibromodulin is a protein that in humans is encoded by the FMOD gene.[1][2]

Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix.[2]

References[edit]

  1. ^ Sztrolovics R, Chen XN, Grover J, Roughley PJ, Korenberg JR (Mar 1995). "Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence". Genomics 23 (3): 715–7. doi:10.1006/geno.1994.1567. PMID 7851907. 
  2. ^ a b "Entrez Gene: FMOD fibromodulin". 

Further reading[edit]