Ficolin

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Ficolins (Fi+Col+Lin) are a group of oligomeric lectins with subunits consisting of both collagen (Col)-like long thin stretches and fibrinogen (Fi)-like globular domains with lectin (Lin) activity usually specific for N-acetylglucosamine (GlcNAc).[1] Like collectins (Col+lectin) such as mannan-binding lectin, ficolins are secreted, lectin-type pattern recognition receptors, and similarly activate the lectin pathway of complement activation.

Examples of human ficolins include:

  1. FCN1
  2. FCN2
  3. FCN3

References[edit]

  1. ^ Matsushita, Misao (2010). "Ficolins: Complement-Activating Lectins Involved in Innate Immunity". Journal of Innate Immunity 2 (1): 24–32. doi:10.1159/000228160. PMID 20375620.