File:Steroidogenesis.svg

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Error-hypervalent-C.svg The factual accuracy of this chemical structure is disputed.
Page last edited by Leyo 11 days ago
The dispute is about: Stereochemistry is missing at several places, even though it is defined (substances are not racemic).

Please discuss the issue on this diagram's talk page

See also: Wikipedia chemical structure drawing guide.
Usage: {{disputed chem|why}} – All: Category:Disputed chemical diagrams
You may want to notify the uploader(s) by placing the following code on their talk page:
{{subst:Disputed chem/notification|Steroidogenesis.svg}}

[edit] Summary

Description
English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

White circles indicate changes in molecular structure compared with precursors.

Where stereochemistry is not shown, it is the same as for or for any functional groups shown for the first time.

HSD: Hydroxysteroid dehydrogenase

References:

  • Walter F. Boron, Emile L. Boulpaep (2003(2003)). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. pp. page 1300. ISBN 1-4160-2328-3.
Note: There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.
Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
Date 28 March 2009(2009-03-28)
Source Self-made using bkchem and inkscape
Author David Richfield (User:Slashme) and Mikael Häggström
Derived from previous version by Hoffmeier and Settersr.
Other versions

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[edit] Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.


[edit] Licensing

GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.

w:en:Creative Commons
attribution share alike		 This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).
  • share alike – If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.
This licensing tag was added to this file as part of the GFDL licensing update.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current05:15, 13 December 2011Thumbnail for version as of 05:15, 13 December 20111,245 × 1,105 (114 KB)Slashme (Align some text and arrows for neatness' sake.)
04:56, 13 December 2011Thumbnail for version as of 04:56, 13 December 20111,245 × 1,105 (114 KB)Slashme (Fixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.)
12:58, 8 May 2010Thumbnail for version as of 12:58, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggström (minor move of 5-a-reductase)
12:56, 8 May 2010Thumbnail for version as of 12:56, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggström (minor renaming of 3-beta-HSD)
06:46, 24 April 2010Thumbnail for version as of 06:46, 24 April 20101,245 × 1,105 (114 KB)Mikael Häggström (Moved name out of molecular structure)
11:53, 13 May 2009Thumbnail for version as of 11:53, 13 May 20091,245 × 1,105 (114 KB)Mikael Häggström (Moved misplaced nr 6 on cholesterol)
11:16, 8 April 2009Thumbnail for version as of 11:16, 8 April 20091,245 × 1,105 (114 KB)Mikael Häggström (Corrected groups. It's cortisol that has mineralocorticoid effects (requiring 11 hydroxysteroid dehydrogenase to be present in the kidneys not to be overwhelmed by this effect), and not the opposite.)
15:55, 2 April 2009Thumbnail for version as of 15:55, 2 April 20091,245 × 1,105 (114 KB)Mikael Häggström (Same stereoisomery for all vertical text.)
06:58, 2 April 2009Thumbnail for version as of 06:58, 2 April 20091,245 × 1,105 (114 KB)Mikael Häggström (Corrected aldosterone structure)
14:48, 31 March 2009Thumbnail for version as of 14:48, 31 March 20091,245 × 1,105 (113 KB)Mikael Häggström (Marked structural changes in molecules)
09:52, 30 March 2009Thumbnail for version as of 09:52, 30 March 20091,245 × 1,105 (101 KB)Mikael Häggström (added border lines)
09:27, 29 March 2009Thumbnail for version as of 09:27, 29 March 20091,245 × 1,105 (97 KB)Mikael Häggström (androstanediol -> androstenediol)
06:22, 29 March 2009Thumbnail for version as of 06:22, 29 March 20091,254 × 1,129 (99 KB)Mikael Häggström (Progestins --> Progestagens (these are not synthetic))
14:33, 28 March 2009Thumbnail for version as of 14:33, 28 March 20091,254 × 1,129 (100 KB)Mikael Häggström (Spelling in androgens)
10:36, 28 March 2009Thumbnail for version as of 10:36, 28 March 20091,244 × 1,119 (100 KB)Mikael Häggström (default text size)
09:43, 28 March 2009Thumbnail for version as of 09:43, 28 March 20091,244 × 1,119 (90 KB)Mikael Häggström (Coloured)
17:17, 19 November 2008Thumbnail for version as of 17:17, 19 November 20081,210 × 1,150 (69 KB)Mikael Häggström ({{Information |Description= |Source= |Date= |Author= |Permission= |other_versions= }})
16:35, 3 August 2008Thumbnail for version as of 16:35, 3 August 20081,210 × 1,080 (53 KB)Slashme (Move aldosterone to bottom for better visibility.)
16:13, 3 August 2008Thumbnail for version as of 16:13, 3 August 20081,475 × 1,080 (55 KB)Slashme ({{Information |Description={{en|1=Enzymes involved in en:steroidogenesis. Where stereochemistry is not shown, it is the same as for Cholesterol or for any functional groups shown for the first time. HSD: Hydroxysteroid dehydrogenase }} |Source=Self)

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