Filtration slits

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Scheme of filtration barrier (blood-urine) in the kidney.
A. The endothelial cells of the glomerulus; 1. pore (fenestra).
B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa
C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragma

Foot processes of podocytes interdigitate with one another forming filtration slits (or slit pores) that, in contrast to those in the glomerular endothelium, are spanned by slit diaphragms.


Some studies suggest that the size of the filtration slits restricts the passage of large molecules (e.g., serum albumin) and cells (e.g., red blood cells and platelets).[1] Proteins that are required for the correct function of the slit diaphragm include nephrin,[2] NEPH1, NEPH2,[3] podocin, and CD2AP.[4]


  1. ^ Jarad, G.; Miner, J. H. (2009). "Update on the glomerular filtration barrier". Current opinion in nephrology and hypertension 18 (3): 226–232. doi:10.1097/mnh.0b013e3283296044. PMC 2895306. PMID 19374010.  edit
  2. ^ Wartiovaara, J.; Ofverstedt, L. G. R.; Khoshnoodi, J.; Zhang, J.; Mäkelä, E.; Sandin, S.; Ruotsalainen, V.; Cheng, R. H.; Jalanko, H.; Skoglund, U.; Tryggvason, K. (2004). "Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography". Journal of Clinical Investigation 114 (10): 1475–1483. doi:10.1172/JCI22562. PMC 525744. PMID 15545998.  edit
  3. ^ Neumann-Haefelin, E.; Kramer-Zucker, A.; Slanchev, K.; Hartleben, B.; Noutsou, F.; Martin, K.; Wanner, N.; Ritter, A.; Gödel, M.; Pagel, P.; Fu, X.; Müller, A.; Baumeister, R.; Walz, G.; Huber, T. B. (2010). "A model organism approach: Defining the role of Neph proteins as regulators of neuron and kidney morphogenesis". Human Molecular Genetics 19 (12): 2347–2359. doi:10.1093/hmg/ddq108. PMID 20233749.  edit
  4. ^ Fukasawa, H.; Bornheimer, S.; Kudlicka, K.; Farquhar, M. G. (2009). "Slit Diaphragms Contain Tight Junction Proteins". Journal of the American Society of Nephrology 20 (7): 1491–1503. doi:10.1681/ASN.2008101117. PMC 2709684. PMID 19478094.  edit

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