Fischer projection
The Fischer projection, devised by Hermann Emil Fischer in 1891,[1] is a two-dimensional representation of a three-dimensional organic molecule by projection. Fischer projections were originally proposed for the depiction of carbohydrates and used by chemists, particularly in organic chemistry and biochemistry. The use of Fischer projections in non-carbohydrates is discouraged, as such drawings are ambiguous when confused with other types of drawing.[2]
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[edit] Conventions
All bonds are depicted as horizontal or vertical lines. The carbon chain is depicted vertically, with carbon atoms represented by the center of crossing lines. The orientation of the carbon chain is so that the C1 carbon is at the top. [3] In an aldose, the carbon of the aldehyde group is C1; in a ketose the carbon of the ketone group has the lowest possible number (usually C2). [4]
A Fischer projection is used to differentiate between L- and D- molecules. On a Fischer projection, the penultimate carbon of D sugars are depicted with hydrogen on the left and hydroxide on the right. L sugars will be shown with the hydrogen on the right and the hydroxide on the left.[5]
In a Fischer projection, all horizontal bonds project toward the viewer, while vertical bonds project away from the viewer. Therefore, a Fischer projection cannot be rotated by 90° or 270° in the plane of the page or the screen, as the orientation of bonds relative to one another can change, converting a molecule to its enantiomer. According to IUPAC rules all hydrogen atoms should preferably be drawn explicitly. Especially the hydrogen atoms of the end group of carbohydrates should be present. [2]
[edit] Usage
Fischer projections are most commonly used in biochemistry and organic chemistry to represent monosaccharides, but can also be used for amino acids or for other organic molecules. Since Fischer projections depict the stereochemistry (three-dimensional structure) of a molecule, they are very useful for differentiating between enantiomers of chiral molecules.
[edit] Other systems
Haworth projections are a related chemical notation used to represent sugars in ring form. The groups on the right hand side of a Fischer projection are equivalent to those below the plane of the ring in Haworth projections.[6] Fischer projections should not be confused with Lewis structures, which do not contain any information about three dimensional geometry.
[edit] See also
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[edit] References
- ^ John McMurry (2008). Organic Chemistry (7th ed.). Brooks/Cole - Thomson Learning, Inc.. pp. 975. ISBN 0132862611.
- ^ a b Graphical representation of stereochemical configuration (IUPAC Recommendations 2006), p.1933-1934
- ^ Understanding Fischer Projection and Angular Line Representation Conversion Luis F. Moreno Journal of Chemical Education 2012 89 (1), 175-176 doi:10.1021/ed101011c
- ^ "Rules of Carbohydrate Nomenclature". The Journal of Organic Chemistry (American Chemical Society) 28 (2): 281–291. February 1963. doi:10.1021/jo01037a001. http://pubs.acs.org/doi/abs/10.1021/jo01037a001.
- ^ "Sugars & Polysaccharides". Rensselaer Polytechnic Institute (RPI). http://rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/sugar.htm. Retrieved 2011-07-10.
- ^ Matthews, C. E.; K. E. Van Holde; K. G. Ahern (1999) Biochemistry. 3rd edition. Benjamin Cummings. ISBN 0-8053-3066-6
