Flavoxate

Flavoxate

Systematic (IUPAC) name
2-(1-piperidyl)ethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682706
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	15301-69-6 Y
ATC code	G04BD02
PubChem	CID 3354
DrugBank	APRD00972
ChemSpider	3237 Y
UNII	3E74Y80MEY Y
KEGG	D07961 Y
ChEBI	CHEBI:5088 Y
ChEMBL	CHEMBL1493 N
Chemical data
Formula	C24H25NO4
Mol. mass	391.46 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3 Y Key:SPIUTQOUKAMGCX-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors.

Clinical uses

Flavoxate is used to treat urinary bladder spasms. It is available under the trade name Urispas (Paladin),Genurin (by Recordati, Italy) in Italy and KSA,Uritac by El Saad company in Syria, under the name Bladderon by Nippon Shinyaku of Japan, or Bladuril in Chile.

Flavoxate is indicated for symptomatic relief of interstitial cystitis, dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.

Side effects

Flavoxate is generally well tolerated, but can potentially cause, vomiting, upset stomach, dry mouth or throat, blurred vision, eye pain, and increased sensitivity of your eyes to light.

Contraindications

Flavoxate is contraindicated in patients who have any of the following obstructive conditions: pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, gastrointestinal hemorrhage and obstructive uropathies of the lower urinary tract.

References

• Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
• Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

• U.S. National Library of Medicine, National Institutes of Health. "Flavoxate". PubMed Health. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000753