Flesinoxan

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Flesinoxan
Flesinoxan.svg
Systematic (IUPAC) name
4-fluoro-N-(2-{4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl}ethyl)benzamide
Clinical data
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 98206-10-1
ATC code None
PubChem CID 57347
ChemSpider 51700
UNII 3V574S89E1 YesY
KEGG D02568
Chemical data
Formula C22H26FN3O4 
Mol. mass 415.458 g/mol

Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class.[1][2][3] Originally developed as a potential antihypertensive drug,[1][2][4] flesinoxan was later found to possess antidepressant and anxiolytic effects in animal tests.[5][6] As a result, it was investigated in several small human pilot studies for the treatment of major depressive disorder, and was found to have robust effectiveness and very good tolerability.[7][8] Unfortunately however, due to "management decisions", the development of flesinoxan was stopped and it was not pursued any further.[9]

In patients, flesinoxan enhances REM sleep latency, decreases body temperature, and increases ACTH, cortisol, prolactin, and growth hormone secretion.[8][2]

See also[edit]

References[edit]

  1. ^ a b Schoeffter P, Hoyer D. (1988). "Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.". Br J Pharmacol. 95 (3): 975–985. doi:10.1111/j.1476-5381.1988.tb11728.x. PMC 1854240. PMID 3207999. 
  2. ^ a b c Pitchot W, Wauthy J, Legros JJ, Ansseau M (March 2004). "Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology 14 (2): 151–5. doi:10.1016/S0924-977X(03)00108-1. PMID 15013031. 
  3. ^ Hadrava V, Blier P, Dennis T, Ortemann C, de Montigny C (October 1995). "Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study". Neuropharmacology 34 (10): 1311–26. doi:10.1016/0028-3908(95)00098-Q. PMID 8570029. 
  4. ^ Wouters W, Tulp MT, Bevan P (May 1988). "Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors". European Journal of Pharmacology 149 (3): 213–23. doi:10.1016/0014-2999(88)90651-6. PMID 2842163. 
  5. ^ van Hest A, van Drimmelen M, Olivier B (1992). "Flesinoxan shows antidepressant activity in a DRL 72-s screen". Psychopharmacology 107 (4): 474–9. doi:10.1007/BF02245258. PMID 1351303. 
  6. ^ Rodgers RJ, Cole JC, Davies A (August 1994). "Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan". Pharmacology, Biochemistry, and Behavior 48 (4): 959–63. doi:10.1016/0091-3057(94)90205-4. PMID 7972301. 
  7. ^ Grof P, Joffe R, Kennedy S, Persad E, Syrotiuk J, Bradford D (1993). "An open study of oral flesinoxan, a 5-HT1A receptor agonist, in treatment-resistant depression". International Clinical Psychopharmacology 8 (3): 167–72. doi:10.1097/00004850-199300830-00005. PMID 8263314. 
  8. ^ a b Marc Ansseau, William Pitchot, Antonio Gonzalez Moreno, Jacques Wauthy, Patrick Papart (2004). "Pilot study of flesinoxan, a 5-HT1A agonist, in major depression: Effects on sleep REM latency and body temperature.". Human Psychopharmacology: Clinical and Experimental 8 (4): 279–283. doi:10.1002/hup.470080407. 
  9. ^ Celada P, Bortolozzi A, Artigas F (September 2013). "Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research". CNS Drugs 27 (9): 703–16. doi:10.1007/s40263-013-0071-0. PMID 23757185.