She was born into a wealthy and prominent family Augusta, Maine and attended Augusta Public Schools and St. Catherine's Hall boarding school. In 1892-93, Whitehouse traveled to Southern Europe and Middle East. In 1894, she married Robert Treat Whitehouse, a lawyer from Augusta and the couple moved to Portland, Maine. She later wrote two romance novels based in the Middle East.
In 1913, she became actively involved in the feminist movement, which eventually led her to picket the White House and fervently oppose Woodrow Wilson for not pursuing women's suffrage. She was Maine chairwoman of the National Women's Party and toured the state, creating local groups across Maine.