Ekpo-Umoh last competed for her birth country Nigeria at the 1994 World Junior Championships. She defected to Germany in 1995 during a training camp there, married her German trainer in 1998 and received German citizenship in 2000. Since 1998, she represented the sports club USC Mainz.
In 2003, Ekpo-Umoh was found guilty of stanozolol doping. The sample was delivered on 24 January 2003 in an out-of-competition test in South Africa. She was suspended from the sport until March 2005. 
Her personal best time is 51.13 seconds, achieved in June 2001 in Stuttgart.