Floxuridine

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Floxuridine
Floxuridine.png
Systematic (IUPAC) name
5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a682006
Legal status
?
Identifiers
CAS number 50-91-9 YesY
ATC code None
PubChem CID 5790
DrugBank DB00322
ChemSpider 5586 YesY
UNII 039LU44I5M YesY
KEGG D04197 YesY
ChEBI CHEBI:60761 YesY
ChEMBL CHEMBL917 YesY
Chemical data
Formula C9H11FN2O5 
Mol. mass 246.192 g/mol
 YesY (what is this?)  (verify)

Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.

Pharmacology[edit]

Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine.

Mechanism of action[edit]

Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.

History[edit]

Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to F H Faulding, which became Mayne Pharma.

Suppliers[edit]

In the US the drug is supplied by APP Pharmaceuticals, LLC; Hospira, Inc.; and Bedford Laboratories.