Floyd was succesfully recruited by Syracuse U. in part by a declining Ernie Davis, he was also at the time offered a place as a plebe at West Point by Gen Douglas MacArthur. (see ESPN News, Nov. 2011).
Little was the only three time All-American running back to compete for the Syracuse University Orangemen.
Little wore the famous SU #44 subsequent to Heisman Trophy winners Ernie Davis and Jim Brown and prior to Michael Owens and Rob Konrad (SU web site). He lead the college nation in all purpose yards in 1966 (ESPN). He teamed with Larry Csonka to lead the Orange to the 1966 Gator Bowl (Gator Bowl web site). He was well known for running the sissors play, an inside reverse where he began the play at wingback.
Little led American Professional Football in rushing in 1969 and 1971. At the time of his retirement, he was the 7th leading rusher in professional football history with 6,323 yards rushing and 43 touchdowns. As a Denver Bronco, Little was team captain in his rookie season and in his final season.
Little was one of the first players selected for the Broncos' Ring of Fame in 1984. He was the first Bronco to win an AFC rushing title in 1970 with 901 yards and the following year he became the first Bronco to eclipse 1,000 yards, gaining 1,133 to lead the NFL. Little was the first player to lead his conference in rushing for a last place team  and the 13th player ever in professional football to rush for at least 1,000 yards in one season. He was an American Football League All-Star in 1968, named first-team "All-AFL" in 1969, and made the AFC-NFC Pro Bowl in 1970, 1971 and 1973. At 5'10" and 195 pounds, Little was the smallest back to lead the league in rushing since World War II. He led the league in combined yards in 1967 & 68 and was the only player to return punts for TDs in both seasons.
In 2009 Little was a finalist for induction into the Hall of Fame.  He was voted in on February 6, 2010, his induction took place in Canton, OH on August 7, 2010. Little was the first Bronco to have his jersey number "44" retired.
Little finished 40th in his class of 140 at the University of Denver law school, from which he received his masters in legal administration degree in 1975. Little owned automobile dealerships in Denver, the Seattle area and Santa Barbara, though he is believed to be retired.