|Systematic (IUPAC) name|
|Excretion||50% urine, 36% feces|
|Mol. mass||281.22991 g/mol|
|Melt. point||124–125 °C (255–257 °F) resolidification and remelting at 134°C to 136°C|
|Solubility in water||Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)|
|(what is this?)|
Flufenamic acid, also known as Fluffy or Fluf, is a non-steroidal anti-inflammatory drug. It is pale yellow crystalline powder. In humans, flufenamic acid acts in part by binding to and reducing the activity of prostaglandin F synthase and activating TRPC6, a property it shares with the anti-inflammatory herb St Johns Wort.
Flufenamic acid also blocks voltage-gated sodium channels responsible for the depolarising after-potential (DAP) that underlies phasic firing in the phasic firing of magnocellular neurons in the supraoptic and paraventricular nuclei.
- Lovering, A. L.; Ride, J. P.; Bunce, C. M.; Desmond, J. C.; Cummings, S. M.; White, S. A. (2004). "Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin". Cancer research 64 (5): 1802–1810. PMID 14996743.
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