Fluocinolone acetonide

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Fluocinolone acetonide
Fluocinolone acetonide.svg
Fluocinolone acetonide (Ball-n-Stick).png
Systematic (IUPAC) name
Clinical data
AHFS/Drugs.com International Drug Names
  • C
Legal status
  • Prescription Only
Routes Topical
Pharmacokinetic data
Metabolism Hepatic, CYP3A4-mediated
Half-life 1.3 to 1.7 hours
CAS number 67-73-2 YesY
ATC code C05AA10 D07AC04 S01BA15 S02BA08
PubChem CID 6215
DrugBank DB00591
ChemSpider 5980 YesY
KEGG D01825 YesY
Chemical data
Formula C24H30F2O6 
Molecular mass 452.488 g/mol
 N (what is this?)  (verify)

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City.[1] Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Flucinolone is a group IV (0.01-0.2%) or group V (0.25%) corticosteroid under US classification.

See also[edit]


  1. ^ J S Mills, A. Bowers, Carl Djerassi and H.J. Ringold, Steroids CXXXVII. Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-Hydroxyprednisolone and its Acetonide, Journal of the American Chemical Society, 80, 3399-3404 (1960)