Fluocinolone acetonide

Fluocinolone acetonide

Systematic (IUPAC) name
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C
Legal status	?
Routes	Topical
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Half-life	1.3 to 1.7 hours
Identifiers
CAS number	67-73-2 Y
ATC code	C05AA10 D07AC04 S01BA15 S02BA08
PubChem	CID 6215
DrugBank	APRD00977
ChemSpider	5980 Y
UNII	0CD5FD6S2M Y
KEGG	D01825 Y
ChEMBL	CHEMBL989 Y
Chemical data
Formula	C24H30F2O6
Mol. mass	452.488 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 Y Key:FEBLZLNTKCEFIT-VSXGLTOVSA-N Y
N (what is this?)  (verify)

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.