Adenosyl-fluoride synthase

From Wikipedia, the free encyclopedia
  (Redirected from Fluorinase)
Jump to: navigation, search
Adenosyl-fluoride synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an adenosyl-fluoride synthase (EC is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + fluoride \rightleftharpoons 5'-deoxy-5'-fluoroadenosine + L-methionine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and fluoride, whereas its two products are 5'deoxy-5'-fluoroadenosine and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:fluoride adenosyltransferase. This enzyme is also called fluorinase.

Structural studies[edit]

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RQP, 1RQR, 2C2W, 2C4T, 2C4U, 2C5B, 2C5H, 2CBX, and 2CC2.

See also[edit]


  • O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD (2002). "Biochemistry: biosynthesis of an organofluorine molecule". Nature. 416 (6878): 279. doi:10.1038/416279a. PMID 11907567. 
  • Naismith JH; Huang, F; Deng, H; Schaffrath, C; Spencer, JB; O'Hagan, D; Naismith, JH (2004). "Crystal structure and mechanism of a bacterial fluorinating enzyme". Nature. 427 (6974): 561–5. doi:10.1038/nature02280. PMID 14765200.