Flurothyl

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Flurothyl
Flurothyl.png
Systematic (IUPAC) name
2,2-oxybis(1,1,1-trifluoroethane)
OR
bis(2,2,2-trifluoroethyl) ether
Clinical data
Legal status ?
Identifiers
CAS number 333-36-8 YesY
ATC code None
PubChem CID 9528
UNII 9Z467FG2YK YesY
Synonyms Hexafluorodiethyl ether
Chemical data
Formula C4H4F6O 
Mol. mass 182.064
Physical data
Density 1.404 g/cm3 g/cm³
 YesY (what is this?)  (verify)

Flurothyl (Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant.[1] Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.[2][3][4] Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.[5][6] This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.[7]

See also: Theories of general anaesthetic action.

References[edit]

  1. ^ Rose, L; Watson, A (1967). "Flurothyl (Indoklon). Experience with an inhalational convulsant agent". Anaesthesia 22 (3): 425–34. PMID 4951597. 
  2. ^ Koblin DD, Chortkoff BS, Laster MJ, Eger EI, Halsey MJ, Ionescu P (December 1994). "Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis". Anesthesia and Analgesia 79 (6): 1043–8. doi:10.1213/00000539-199412000-00004. PMID 7978424. 
  3. ^ Koblin DD, Laster MJ, Ionescu P, Gong D, Eger EI, Halsey MJ, Hudlicky T (May 1999). "Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties". Anesthesia and Analgesia 88 (5): 1161–7. doi:10.1213/00000539-199905000-00036. PMID 10320188. 
  4. ^ Eger EI, Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR (June 1999). "Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart". Anesthesia and Analgesia 88 (6): 1395–400. doi:10.1213/00000539-199906000-00036. PMID 10357351. 
  5. ^ "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA: the Journal of the American Medical Association 196 (1): 29–30. 1966. doi:10.1001/jama.196.1.29. PMID 4379572. 
  6. ^ Small, JG; Small, IF; Sharpley, P; Moore, DF (1968). "A double-blind comparative evaluation of flurothyl and ECT". Archives of General Psychiatry 19 (1): 79–86. doi:10.1001/archpsyc.1968.01740070081012. PMID 5658383. 
  7. ^ Hashimoto, Y; Araki, H; Suemaru, K; Gomita, Y (2006). "Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils". European Journal of Pharmacology 536 (3): 241–7. doi:10.1016/j.ejphar.2006.02.036. PMID 16581068.