|Systematic (IUPAC) name|
|Density||1.404 g/cm3 g/cm³|
| (what is this?)
Flurothyl (Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant. Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs. Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy. This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.
- Rose, L; Watson, A (1967). "Flurothyl (Indoklon). Experience with an inhalational convulsant agent". Anaesthesia 22 (3): 425–34. PMID 4951597.
- Koblin DD, Chortkoff BS, Laster MJ, Eger EI, Halsey MJ, Ionescu P (December 1994). "Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis". Anesthesia and Analgesia 79 (6): 1043–8. doi:10.1213/00000539-199412000-00004. PMID 7978424.
- Koblin DD, Laster MJ, Ionescu P, Gong D, Eger EI, Halsey MJ, Hudlicky T (May 1999). "Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties". Anesthesia and Analgesia 88 (5): 1161–7. doi:10.1213/00000539-199905000-00036. PMID 10320188.
- Eger EI, Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR (June 1999). "Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart". Anesthesia and Analgesia 88 (6): 1395–400. doi:10.1213/00000539-199906000-00036. PMID 10357351.
- "A convulsant agent for psychiatric use. Flurothyl (Indoklon)". JAMA: the Journal of the American Medical Association 196 (1): 29–30. 1966. doi:10.1001/jama.196.1.29. PMID 4379572.
- Small, JG; Small, IF; Sharpley, P; Moore, DF (1968). "A double-blind comparative evaluation of flurothyl and ECT". Archives of General Psychiatry 19 (1): 79–86. doi:10.1001/archpsyc.1968.01740070081012. PMID 5658383.
- Hashimoto, Y; Araki, H; Suemaru, K; Gomita, Y (2006). "Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils". European Journal of Pharmacology 536 (3): 241–7. doi:10.1016/j.ejphar.2006.02.036. PMID 16581068.