Fluspirilene

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Fluspirilene
Fluspirilen.svg
Systematic (IUPAC) name
8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes IM
Identifiers
CAS number 1841-19-6
ATC code N05AG01
PubChem CID 3396
IUPHAR ligand 85
DrugBank DB04842
ChemSpider 3279 YesY
UNII C5QA4GLR9M YesY
KEGG D02629 YesY
ChEMBL CHEMBL46516 YesY
Chemical data
Formula C29H31F2N3O 
Mol. mass 475.573 g/mol
 YesY (what is this?)  (verify)

Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia.[1] It is administered intramuscularly.[2] It was discovered at Janssen Pharmaceutica in 1963.[3]

Chemistry[edit]

Fluspirilene can be synthesized starting from benzyl-piperidone and aniline.[3][4][5]

Fluspirilene synthesis.png

See also[edit]

References[edit]

  1. ^ van Epen JH (1970). "Experience with fluspirilene (R 6218), a long-acting neuroleptic". Psychiatr Neurol Neurochir 73 (4): 277–284. PMID 5478771. 
  2. ^ Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Herin VV, Schaper WK (1970). "The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug". Arzneimittelforschung 20 (11): 1689–1698. PMID 4992598. 
  3. ^ a b C. Janssen, NV Res. Lab., BE 633914  (1963)
  4. ^ P.A.J. Janssen, U.S. Patent 3,238,216 (1966)
  5. ^ P.A.J. Janssen, DE 1470125  (1963)