Flutazolam

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Flutazolam
Flutazolam.svg
Flutazolam ball-and-stick.png
Systematic (IUPAC) name
10-chloro- 11b-(2-fluorophenyl)- 7-(2-hydroxyethyl)- 3,5-dihydro- 2H-[1,3]oxazolo [3,2-d][1,4]benzodiazepin- 6-one
Clinical data
Trade names Coreminal(Japan)
AHFS/Drugs.com International Drug Names
Legal status
  • US: Unscheduled
  • Unscheduled (Japan: Prescription only)
Pharmacokinetic data
Metabolism Hepatic
Half-life 3.5 hours
Identifiers
CAS number 27060-91-9 N
ATC code None
PubChem CID 3398
ChemSpider 3281 YesY
UNII 5G2K7O5D8S YesY
KEGG D01286 YesY
ChEMBL CHEMBL1697836 N
Synonyms 13-chloro- 2-(2-fluorophenyl)- 9-(2-hydroxyethyl)- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca-1(10),11,13- trien- 8-one
Chemical data
Formula C19H18ClFN2O3 
Mol. mass 376.809
 N (what is this?)  (verify)

Flutazolam[1] (Coreminal, MS-4101) is a drug which is a benzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and though it's around the same potency as diazepam, it produces a more marked sedation and impaired coordination. It is indicated for the treatment of insomnia.[2]

Flutazolam is closely related in structure to another benzodiazepine, haloxazolam.[3][4]

See also[edit]

References[edit]

  1. ^ DE Patent 1952486
  2. ^ Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101). Nippon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. (Japanese).
  3. ^ Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chemical and Pharmaceutical Bulletin (Tokyo). 1986 Jan;34(1):320-6.
  4. ^ Yashiro T, Kuwayama T, Kawazura H, Suzuki T. The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system. Journal of the Pharmaceutical Society of Japan. 1987 Oct;107(10):830-4. (Japanese).