Fluticasone

Fluticasone
Systematic (IUPAC) name
	S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-; 6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-; 6,7,8,11,12,14,15,16-octahydrocyclopenta[a]; phenanthrene-17-carbothioate
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C for Intranasal and Inhaled
Legal status	POM (UK) ℞-only (US)
Routes	Intranasal, Inhaled, Topical Cream or Ointment
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91%
Metabolism	Intranasal; Hepatic (CYP3A4-mediated)
Half-life	10 hours
Excretion	Renal
Identifiers
CAS number	90566-53-3 ; 80474-14-2 (propionate)
ATC code	D07AC17 & D07AC04 (topical)
PubChem	CID 5311101
DrugBank	APRD00065
ChemSpider	4470631
UNII	CUT2W21N7U
KEGG	D07981
ChEMBL	CHEMBL1201396
Chemical data
Formula	C22H27F3O4S
Mol. mass	444.508 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:MGNNYOODZCAHBA-GQKYHHCASA-N ;
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Not to be confused with fluconazole.

Fluticasone is a synthetic glucocorticoid.

Both the furoate and propionate forms are used as topical anti-inflammatories:

Treatment of asthma - Fluticasone in combination with Salmeterol - "[1]" - aerosol.

[edit] See also