This street runs through the neighborhood of University Heights, divides Fordham from Fordham-Bedford and finally runs along the northern border of Belmont. It begins at its eastern point as a continuation of Pelham Parkway and at its western point, continues over the University Heights Bridge into Manhattan, where it runs as West 207th Street. It is a two-way, four-lane road. East of Webster Avenue Fordham Road runs concurrent with U.S. Route 1 from Webster Avenue to Boston Road.
Fordham Road is divided into East Fordham Road and West Fordham Road by Jerome Avenue following after the Manhattan grid, with address numbers for both the East Fordham Road and West Fordham Road increasing away from Jerome Avenue.
East of Webster Avenue and directly across from Fordham University, at Fordham Plaza, is a major hub for buses and a stop on the Metro-North Railroad's Harlem and New Haven lines. The Hudson Line also stops at the University Heights station. Fordham Road is served by the New York City Subway at Jerome Avenue (4 train) and Grand Concourse (B D trains). There was formerly a stop at Third Avenue before 1973.
- St. Nicholas of Tolentine's Church is a prominent landmark on West Fordham Road at University Avenue in University Heights.
- Rose Hill Campus of Fordham University is at 441 East Fordham Road.
- Theodore Roosevelt High School is on the other side of Fordham Road from Fordham University.
- The Bronx Zoo and New York Botanical Garden are at the eastern terminus of Fordham Road in Bronx Park.