Foreign-body giant cell

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Histopathologic image of aspiration pneumonia in an elderly patient with debilitating neurologic illness. Note foreign-body giant cell reaction. Autopsy case. H & E stain.

A foreign-body giant cell is a collection of fused macrophages (giant cell) which are generated in response to the presence of a large foreign body. This is particularly evident with implants that cause the body chronic inflammation and foreign body response.[1] This reaction to the implant causes damages to the infected area, leaving the exterior surface with scars. [2]

The nuclei are arranged in a disorganized manner.[3] The nuclei in this cell are centrally placed and overlap each other. [4] This is in contrast to a Langhans giant cell, where the nuclei are arranged on the border.

Additional images[edit]

Small image of an infected area of the body due to a reaction with an implant


  1. ^ Foreign Body Giant Cell at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ Mcnally, Amy. "Giant Cell Formation". Retrieved May 21, 2013. 
  3. ^ "Inflammation". 
  4. ^ "Giant cells in chronic inflammation". Retrieved May 21, 2013.