Formate C-acetyltransferase

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formate C-acetyltransferase
Identifiers
EC number 2.3.1.54
CAS number 9068-08-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a formate C-acetyltransferase (EC 2.3.1.54) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + formate \rightleftharpoons CoA + pyruvate

Thus, the two substrates of this enzyme are acetyl-CoA and formate, whereas its two products are CoA and pyruvate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:formate C-acetyltransferase. Other names in common use include pyruvate formate-lyase, pyruvic formate-lyase, and formate acetyltransferase. This enzyme participates in 3 metabolic pathways: pyruvate metabolism, propanoate metabolism, and butanoate metabolism.

Structural studies[edit]

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1CM5, 1H16, 1H17, 1H18, 1MZO, 1QHM, 2PFL, and 3PFL.

References[edit]