Formyl peptide receptor 2

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Formyl peptide receptor 2
Identifiers
Symbols FPR2 ; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
External IDs OMIM136538 MGI1278319 HomoloGene74395 IUPHAR: 223 ChEMBL: 4227 GeneCards: FPR2 Gene
RNA expression pattern
PBB GE FPRL1 210772 at tn.png
PBB GE FPRL1 210773 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2358 14289
Ensembl ENSG00000171049 ENSMUSG00000052270
UniProt P25090 O88536
RefSeq (mRNA) NM_001005738 NM_008039
RefSeq (protein) NP_001005738 NP_032065
Location (UCSC) Chr 19:
52.26 – 52.27 Mb
Chr 17:
17.89 – 17.89 Mb
PubMed search [1] [2]

N-formyl peptide receptor 2 or FPR2 is a G-protein coupled receptor (GPCR) protein that in humans is encoded by the FPR2 gene.[1][2] This receptor is also termed the LXA4 or ALX/FPR2 receptor. Described as the receptor for the arachidonic acid metabolite, lipoxin A4 (LXA4), and thereafter for a related arachidonic acid metabolite, Aspirin-triggered lipoxin A4 (ATL, 15-epi-LXA4),[3][4][5] this receptor was previously known as an orphan receptor, termed RFP, obtained by screening myeloid cell-derived libraries with a well-known leukocyte chemotactic factor, N-Formylmethionine leucyl-phenylalanine tripeptide (i.e. FMLP) probe.[6][7][8] In addition to LXA4, LTA, and FMLP, it is now known that FPR2 binds a wide range of structurally very different agents including the docosahexaenoic acid metabolites, Resolvins D1 and D2, a variety of formulated and unformylated oligopeptides, the Cathelicidin antimicrobial polypeptide LL37, host-derived amyloidogenic peptides, and proteins such as PSMA3 (i.e. proteasome subunit alpha type-3) and Annexin A1[9] The most studied role for FPR2 receptors is in mediating the actions of the cited lipoxins and resolvins in dampening and resolving a wide range of inflammatory reactions; these receptors may also be involved in the development of obesity, cognitive decline, reproduction, neuroprotection, and cancer.[10]


See also[edit]

References[edit]

  1. ^ Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN (Apr 1997). "Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor". J Biol Chem 272 (11): 6972–8. doi:10.1074/jbc.272.11.6972. PMID 9054386. 
  2. ^ "Entrez Gene: FPRL1 Formyl peptide receptor-like 1". 
  3. ^ Blood. 1993 Jun 15;81(12):3395-403
  4. ^ J Exp Med. 1994 Jul 1;180(1):253-60
  5. ^ Am J Pathol. 2001 Jan;158(1):3-9
  6. ^ Biochemistry. 1990 Dec 18;29(50):11123-33
  7. ^ J Biol Chem. 1992 Apr 15;267(11):7637-43
  8. ^ Gene. 1992 Sep 10;118(2):303-4
  9. ^ Br J Pharmacol. 2014 Aug;171(15):3551-74. doi: 10.1111/bph.12665
  10. ^ min Immunol. 2015 Apr 6. pii: S1044-5323(15)00012-3. doi: 10.1016/j.smim.2015.03.004

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.