N-formyl peptide receptor 2 or FPR2 is a G-protein coupled receptor (GPCR) protein that in humans is encoded by the FPR2gene. This receptor is also termed the LXA4 or ALX/FPR2 receptor. Described as the receptor for the arachidonic acid metabolite, lipoxin A4 (LXA4), and thereafter for a related arachidonic acid metabolite, Aspirin-triggered lipoxin A4 (ATL, 15-epi-LXA4), this receptor was previously known as an orphan receptor, termed RFP, obtained by screening myeloid cell-derived libraries with a well-known leukocyte chemotactic factor, N-Formylmethionine leucyl-phenylalanine tripeptide (i.e. FMLP) probe. In addition to LXA4, LTA, and FMLP, it is now known that FPR2 binds a wide range of structurally very different agents including the docosahexaenoic acid metabolites, Resolvins D1 and D2, a variety of formulated and unformylated oligopeptides, the Cathelicidin antimicrobial polypeptide LL37, host-derived amyloidogenic peptides, and proteins such as PSMA3 (i.e. proteasome subunit alpha type-3) and Annexin A1 The most studied role for FPR2 receptors is in mediating the actions of the cited lipoxins and resolvins in dampening and resolving a wide range of inflammatory reactions; these receptors may also be involved in the development of obesity, cognitive decline, reproduction, neuroprotection, and cancer.
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