Formyl peptide receptor 2

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Formyl peptide receptor 2
Identifiers
Symbols FPR2 ; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
External IDs OMIM136538 MGI1278319 HomoloGene74395 IUPHAR: FPR2/ALX ChEMBL: 4227 GeneCards: FPR2 Gene
RNA expression pattern
PBB GE FPRL1 210772 at tn.png
PBB GE FPRL1 210773 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2358 14289
Ensembl ENSG00000171049 ENSMUSG00000052270
UniProt P25090 O88536
RefSeq (mRNA) NM_001005738 NM_008039
RefSeq (protein) NP_001005738 NP_032065
Location (UCSC) Chr 19:
52.26 – 52.27 Mb
Chr 17:
17.89 – 17.89 Mb
PubMed search [1] [2]

N-formyl peptide receptor 2 is a G-protein coupled receptor (GPCR) protein that in humans is encoded by the FPR2 gene.[1][2]


See also[edit]

References[edit]

  1. ^ Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN (Apr 1997). "Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor". J Biol Chem 272 (11): 6972–8. doi:10.1074/jbc.272.11.6972. PMID 9054386. 
  2. ^ "Entrez Gene: FPRL1 Formyl peptide receptor-like 1". 

External links[edit]

Further reading[edit]

  • Murphy PM, Ozçelik T, Kenney RT, et al. (1992). "A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.". J. Biol. Chem. 267 (11): 7637–43. PMID 1373134. 
  • Ye RD, Cavanagh SL, Quehenberger O, et al. (1992). "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.". Biochem. Biophys. Res. Commun. 184 (2): 582–9. doi:10.1016/0006-291X(92)90629-Y. PMID 1374236. 
  • Perez HD, Holmes R, Kelly E, et al. (1992). "Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils.". Gene 118 (2): 303–4. doi:10.1016/0378-1119(92)90208-7. PMID 1511907. 
  • Bao L, Gerard NP, Eddy RL, et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.". Genomics 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.". Int. Immunol. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  • Durstin M, Gao JL, Tiffany HL, et al. (1994). "Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.". Biochem. Biophys. Res. Commun. 201 (1): 174–9. doi:10.1006/bbrc.1994.1685. PMID 8198572. 
  • Takano T, Fiore S, Maddox JF, et al. (1997). "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.". J. Exp. Med. 185 (9): 1693–704. doi:10.1084/jem.185.9.1693. PMID 9151906. 
  • Gronert K, Gewirtz A, Madara JL, Serhan CN (1998). "Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.". J. Exp. Med. 187 (8): 1285–94. doi:10.1084/jem.187.8.1285. PMID 9547339. 
  • Deng X, Ueda H, Su SB, et al. (1999). "A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R.". Blood 94 (4): 1165–73. PMID 10438703. 
  • Chiang N, Fierro IM, Gronert K, Serhan CN (2000). "Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation.". J. Exp. Med. 191 (7): 1197–208. doi:10.1084/jem.191.7.1197. PMID 10748237. 
  • Shen W, Proost P, Li B, et al. (2000). "Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines.". Biochem. Biophys. Res. Commun. 272 (1): 276–83. doi:10.1006/bbrc.2000.2770. PMID 10872839. 
  • Le Y, Jiang S, Hu J, et al. (2000). "N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.". Clin. Immunol. 96 (3): 236–42. doi:10.1006/clim.2000.4896. PMID 10964542. 
  • De Yang , Chen Q, Schmidt AP, et al. (2000). "LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.". J. Exp. Med. 192 (7): 1069–74. doi:10.1084/jem.192.7.1069. PMC 2193321. PMID 11015447. 
  • Kang Y, Taddeo B, Varai G, et al. (2000). "Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.". Biochemistry 39 (44): 13551–7. doi:10.1021/bi001196i. PMID 11063592. 
  • Svensson L, Dahlgren C, Wennerås C (2002). "The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1.". J. Leukoc. Biol. 72 (4): 810–8. PMID 12377951. 
  • He R, Sang H, Ye RD (2003). "Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R.". Blood 101 (4): 1572–81. doi:10.1182/blood-2002-05-1431. PMID 12393391. 
  • Christophe T, Karlsson A, Rabiet MJ, et al. (2002). "Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.". Scand. J. Immunol. 56 (5): 470–6. doi:10.1046/j.1365-3083.2002.01149.x. PMID 12410796. 
  • Kucharzik T, Gewirtz AT, Merlin D, et al. (2003). "Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium.". Am. J. Physiol., Cell Physiol. 284 (4): C888–96. doi:10.1152/ajpcell.00507.2001. PMID 12456400. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.