In the late 17th century the site was occupied, perhaps intermittently, by members of the d'Ailleboust family, who used "sieur de Coulonge" as a title. Accounts differ: the Commission de toponymie du Québec mentions Nicholas d'Ailleboust de Manthet, who wintered in that location in 1694; Elizabeth Browne Losey says it was founded by the d'Ailleboust family 'as early as 1650'. With the fall of New France it was abandoned. Before 1800 it was re-occupied by the North West Company, who gave it its present name. When the Hudson's Bay Company took over in 1821 it continued to be supplied from Montreal. Until 1828 it was the head post on the Ottawa River. The post engaged in farming as well as trading. After 1830, as the area became more settled, it became more like a general store. The post's 655-acre (2.651 km2) farm was sold in 1844. In 1855 the surviving store was sold to Thomas Taylor, its last clerk. The buildings were still standing in 1873 but by 1892 they had burned down.
The trading post became the village of Fort-Coulonge situated several kilometres down river.
The region's first sawmill was built by George Bryson, Sr., in 1843. The first wooden chapel was built in 1873. It was destroyed by fire and replaced by a brick church in 1884. In 1886, the railway reached Fort-Coulonge. Fort-Coulonge became a municipality in 1888 and John Bryson was the first mayor.