Fotemustine

Fotemustine

Systematic (IUPAC) name
(RS)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino} ethyl)phosphonate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	92118-27-9
ATC code	L01AD05
PubChem	CID 104799
DrugBank	DB04106
ChemSpider	94600 Y
UNII	GQ7JL9P5I2 Y
KEGG	D07255 Y
ChEMBL	CHEMBL549386 Y
Chemical data
Formula	C9H19ClN3O5P
Mol. mass	315.691 g/mol
SMILES O=P(OCC)(OCC)C(NC(=O)N(N=O)CCCl)C
InChI InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14) Y Key:YAKWPXVTIGTRJH-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. A study has shown that fotemustine produces improved response rates and but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067). There was also toxicity prevalence in fotemustine arm. The main toxicity was grade 3 to 4 neutropenia (51% with fotemustine v 5% with DTIC) and thrombocytopenia (43% v 6%, respectively).