Menzocchi was also called il Vecchio di San Bernardo. He apprenticed first with painter Marco Palmegiani, and later Girolamo Genga. He worked under the latter in the Villa Imperiale in Pesaro, where he would influence Raffaellino del Colle. He frescoed the Sacrifice of Melchisedec and the Miracle of the manna for the chapel of San Francesco di Paula in the Basilica of Loreto. At Forlì, he painted a Trinity for the church of Santa Maria della Grata. His sons, Pier Paolo, and Sebastiano, were also painters. His biography was featured in the Vite by Giorgio Vasari.