Born in Pant-y-beiliau, Llanelli, he was educated at Rugby School and Wadham College, Oxford. He took his B.A. in 1868 and M.A. in 1870. He was a Fellow of Jesus College, Oxford between 1868 and 1873.
From 1879 to 1886, Jayne was Principal of St David's College, a university institution in the small Welsh town of Lampeter. During his time there, he steered the institution through the difficult years following the 1880 Aberdare report on intermediate and higher education in Wales. The report recommended that the Colleges at Aberystwyth and Lampeter be united to form one institution, but Jayne fought the plan and retained St. David's College's independence.
A devoutly religious man, Jayne left Lampeter to become an Anglican vicar in Leeds. He became Bishop of Chester in 1889, a position he held until 1919. He died at Oswestry, and was buried at Bowdon, Cheshire.
- Price, D. T. W (January 2007). "Jayne, Francis John (1845–1921)". Oxford Dictionary of National Biography (online edition, subscription access). Oxford University Press. Retrieved 2008-02-11.
- "The Right Rev. Francis John Jayne". Aberdeen Journal (British Newspaper Archive). 25 August 1921. (subscription required (. ))
|Principal of St David's College
|Church of England titles|
|Bishop of Chester