|This article does not cite any references or sources. (August 2010)|
|Competitor for the United States|
|Gold||1928 Amsterdam||4x100 m relay|
|Gold||1932 Los Angeles||4x100 m relay|
|Gold||1936 Berlin||4x100 m relay|
Wykoff made his debut at the Olympic Games in Amsterdam, where he finished fourth in the 100 m and ran an opening leg in the American 4x100 m relay team, which equalled the world record of 41.0 seconds in the final.
After the Olympics, in 1929, Wykoff enrolled at Glendale Community College. He enrolled for one year to be able to train one more season with his Glendale High School coach, Normal Hayhurst. He was close to death the previous fall with a severe throat infection but recovered enough in the spring to tie the world record four times as a sprinter for Glendale. He then transferred to the University of Southern California where he came under the tutelage of the famous coach Dean Cromwell. He won the AAU championships in 100 yd in 1928 and 1931 and NCAA championships in 100 yd in 1930 and 1931. He ran a new world record in 100 yd of 9.4 s in May, 1930 and repeated it a month later. In 1931, as an anchor of the University of Southern California 4x100 m relay team, he set a new world record of 40.8. While at USC, Wykoff became a member of the Kappa Alpha Order national fraternity.
At the 1932 Summer Olympics, Wykoff ran the fourth leg in a world record (40.0 s) setting American 4x100 m relay team. At the 1936 Summer Olympics he again finished fourth in 100 m and again anchored the American 4x100 m relay team to gold with a new world record of 39.8.
Following his graduation from USC in 1932 Wykoff earned a master's degree in 1936 and became a teacher and administrator. Wykoff worked for the Los Angeles County school system until retiring in 1972. Frank Wykoff died in Altadena, California, aged 70.
A slogan of Wykoff's, "Clean Speech, Clean Sport, Clean Scholarship, Clean Life," was adopted by the YMCA in 1938.