Rottensteiner studied journalism, English and history at the University of Vienna, receiving his doctorate in 1969. He served about fifteen years as librarian and editor at the Österreichisches Institut für Bauforschung in Vienna. In addition, he produced a number of translations into German of leading SF authors, including Herbert W. Franke, Stanislaw Lem, Philip K. Dick, Kobo Abe, Cordwainer Smith, Brian W. Aldiss and the Strugatski brothers.
In 1973 his New York anthology View From Another Shore of European science fiction introduced a number of continental authors to the English-reading public. Some of the authors in the work are Stanislaw Lem, Josef Nesvadba, Gerard Klein and Jean-Pierre Andrevon.
The year 1975 saw the start of his series Die phantastischen Romane. For seven years it re-published works of both lesser- and better-known writers as well as new ones, ending with a total of 28 volumes. In the years 1979-1985 he brought out trnaslations of H. G. Wells's works in an eighteen volumes series.
Rottensteiner provoked some controversy with his negative assessment of American science fiction; "what matters is the highest achievements, and there the US has yet to produce a figure comparable to H.G. Wells, Olaf Stapledon, Karel Čapek or Stanisław Lem."  Rottensteiner described Roger Zelazny, Barry N. Malzberg, and Robert Silverberg as producing "travesties of fiction"  and stated "Asimov is a typical non-writer, and Heinlein and Anderson are just banal".  However, Rottensteiner praised Philip K. Dick, listing him as one of "the greatest SF writers". 
From 1980 through 1998 he was advisor for Suhrkamp Verlag's Phantastische Bibliothek, which brought out some three hundred books. In all, he has edited about fifty anthologies, produced two illustrated books (The Science Fiction Book (1975) und The Fantasy Book (1978)) as well as working on numerous reference works on science fiction.
Rottensteiner has been the editor of Quarber Merkur, the leading German language critical journal of science fiction, since 1963. In 2004, on the occasion of the hundredth number of this journal, he was awarded a special Kurd-Laßwitz-Preis.
- "Recent Writings on German Science Fiction," Science Fiction Studies, Vol. 28, No. 2 (Jul., 2001), pp. 284–290.
- Franz Rottensteiner and Todd C. Hanlin (Translator) The Best of Austrian Science Fiction. (Studies in Austrian Literature, Culture, and Thought. Translation Series. (Aug., 2001)
- "SF in Germany: A Short Survey," Science Fiction Studies, Vol. 27, No. 1 (Mar., 2000), pp. 118–123.
- "Science Fiction: Eine Einführung." Insel Almanach auf das Jahr (1972): 5-21.
- Science Fiction and Fantasy Literature A Checklist, 1700-1974 : with Contemporary Science Fiction Authors II Robert Reginald, Douglas Menville, Mary A. Burgess Detroit - Gale Research Company. ISBN 0810310511 (p.1056)
- Franz Rottensteiner, "Introduction" to View From Another Shore, Liverpool University Press, 1999.ISBN 0853239320 (p. xvi)
- "KLP 2004 Preisträger". Kurd-lasswitz-preis.de. Retrieved 2012-12-23.