Fredrick Barthelme (born October 10, 1943) is an American novelist and short story author, well known as one of the seminal writers of minimalist fiction. Alongside his personal publishing history, his position as Director of The Center For Writers at The University of Southern Mississippi  and Editor of the nationally prominent literary journal Mississippi Review (1977 - 2010) have placed him at the forefront of the contemporary American literary scene. He is currently the editor of New World Writing (formerly Blip Magazine)
Barthelme was born in Houston, Texas. His father, Donald Barthelme, Sr., was a well-known and highly active Modernist architect in the city. The atmosphere of intellectual and aesthetic vigor encouraged by their father, pervasive in Barthelme family life, is described in Double Down: Reflections on Gambling and Loss, a memoir co-written by Frederick and his brother, Steven. His other brothers, Donald and Peter, emerged from the creative household to become authors as well. Frederick pursued his widely-ranging talents in multiple creative fields, including painting and music: he was a founding member of the avant-garde psychedelic rock band The Red Krayola. He eventually chose to focus on fiction writing: receiving his M.A. in creative writing from Johns Hopkins University, where he studied with the influential novelist John Barth.
Barthelme's works are known for their focus on the landscape of the New South. Along with his reputation as a minimalist, together with writers Raymond Carver, Ann Beattie, Amy Hempel, and Mary Robison, Barthelme's work has also been described by terms such as "dirty realism" and "Kmart realism".  He published his first short story in The New Yorker, and has claimed that a rotisserie chicken helped him understand that he needed to write about ordinary people. He has moved away from the postmodern stylings of his older brother, Donald Barthelme, though his brother's influence can be seen in his earliest works, Rangoon and War and War.
Barthelme was thirty-three year editor and visionary of Mississippi Review, known for recognizing and publishing once new talents such as Larry Brown, Curtis Sittenfeld, and Amy Hempel early in their careers. Issues of Mississippi Review have been guest-edited by authors Rick Moody and Mary Robison among others.
- 1976-77 Eliot Coleman Award for prose from Johns Hopkins University for his short story, “Storyteller.”
- 1979, 1980 National Endowment for the Arts grant
- 2004 PEN/Faulkner Award for Fiction nomination for Elroy Nights.
- 2010 Mississippi Institute of Arts and Letters fiction award for Waveland
- Rangoon 1970.
- Moon Deluxe Simon & Schuster, 1983.
- Chroma Simon & Schuster, 1987.
- The Law of Averages: New & Selected Stories Counterpoint, 2000.
- War and War 1971.
- Second Marriage New York: Simon & Schuster, 1984.
- Tracer New York: Simon & Schuster, 1985.
- Two Against One New York: Weidenfeld & Nicolson, 1988.
- Natural Selection New York: Viking, 1989.
- The Brothers New York: Viking, 1993.
- Painted Desert New York: Viking, 1995.
- Bob the Gambler Boston: Houghton-Mifflin, 1997.
- Elroy Nights Cambridge: Counterpoint, 2003.
- Waveland New York: Doubleday, 2009.
- There Must Be Some Mistake New York: Little Brown, 2014.
- (With Steven Barthelme) Double Down: Reflections on Gambling and Loss. Boston: Houghton Mifflin, 1999.
- Second Marriage 1985.
- Tracer 1986.
- "Fredrick Barthelme". The Mississippi Writers Page. The University of Mississippi, English Department. November 11, 2008. Retrieved May 24, 2010.
- Brinkmeyer, Robert H. “Suburban Culture, Imaginative Wonder: The Fiction of Frederick Barthelme.” Studies in the Literary Imagination 27 (Fall 1994): 105-1.
- Hughes, John C. The Novels and Short Stories of Frederick Barthelme: A Literary Critical Analysis. Lewiston: Mellen: 2005. ISBN 0773461779
- Peters, Timothy. “The Eighties Pastoral: Frederick Barthelme’s Moon Deluxe Ten Years On.” Studies in Short Fiction 31.2 (Spring 1994): 175-95.