Frederick Ernst Melsheimer, M.D. (1782-1873; first name also spelled Friedrich) was an American entomologist noted for his work on Coleoptera. He was President of the American Entomological Society in 1853. Frederick Ernest Melsheimer's most important work was Catalogue of the described Coleoptera of the United States (1853). His co-authors on that work were John LeConte and S.S. Haldeman. His father, Frederick Valentine Melsheimer (1749 - 1814) was also an entomologist, as was his elder brother, John Frederick Melsheimer (1780-1829).
- Headrick, David; George Gordh (2003). A Dictionary of Entomology. Wallingford, United Kingdom: CABI Publishing. p. 566. ISBN 978-0-85199-655-4.
- "Melsheimer, Friedrich Ernst (Biodiversity Heritage Library)". Retrieved 13 June 2010.
- H. A. Hagen (1883), "The Melsheimer Family and the Melsheimer Collection", The Canadian Entomologist, Entomological Society of Canada, pp. 191–197
- Prowell, George (1903). Frederick Valentine Melsheimer, a pioneer entomologist, and a noted clergyman and author. York County, Pennsylvania: Historical Society of York County, Pennsylvania. pp. 1–26. Retrieved 13 June 2010.
- "Melsheimer, Frederick Ernest (manuscript notes)". Retrieved 14 June 2010.