Cover to the British "My Timing Is Off" single, featuring "Fresh Blood" as a B-Side
"Fresh Blood" is the first single from the 2009 Eels album Hombre Lobo. On March 31, 2009, the band made the track available on Spinner.com, explaining that the song would be the lead single for the album. The song is about a werewolf who desires "fresh blood". E has described the song as a sequel to "I Want to Protect You".
A 7" single was released on May 18, 2009, in the United Kingdom featuring the album track "My Timing Is Off" as an A-side backed with "Fresh Blood". Both singles were made available on the iTunes Store.
The song was featured in the sixth season episode "Legacy" of the TV series Rescue Me and the end credits of the third season episode "Fresh Blood" of the series True Blood.