Located halfway between the Beaufort and Hunting Island State Park, the Frogmore area is primarily rural but is considered to be the commercial center of St. Helena Island. Frogmore is also the name of a plantation that has been listed on the National Register of Historic Places. The plantation is located off Seaside Road on Frogmore Manor Drive and is significant for its association with Laura Towne and Ellen Murray, the founders of Penn School.
Frogmore is renowned for being home to the Penn School Historic District, known as Penn Center, a National Historic Landmark. Dr. Martin Luther King, Jr. studied and lectured at Penn Center during the formative years of his career as a civil rights leader. The museum at Penn Center is a noted cultural attraction and attracts tourists worldwide who are also interested in learning more about this region of the coastal Southeastern United States.