After working at now-defunct Long-Term Credit Bank of Japan and then as a secretary to a member of the House of Representatives, Kishida was elected for the first time in July 1993. He served in the lower house seven times, representing the Hiroshima No: 1. He was chairman of the LDP's Diet affairs committee until September 2012. In the LDP, he is close to retired veteran LDP politician Makoto Koga. Kishida assumed the control of Koga's faction in October 2012. His most appointment in the LDP was chairman of the headquarters for Japan's economic revitalization.
Kishida was the minister of Okinawa affairs from 2007 to 2008, firstly in the Abe Cabinet and later in the Fukuda cabinet. He was appointed state minister in charge of consumer affairs and food safety in the cabinet of then prime minister Yasuo Fukuda in 2008. Kishida was also state minister in charge of science and technology in the Fukuda cabinet. Kishida was named foreign minister in the Cabinet of Prime Minister Shinzō Abe on 26 December 2012.